Difference between revisions of "JAN 23"

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==2. JAN 23: Unit 1: Food, Health, and Nutrition==
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==4: JAN 23. ==
  
===Assigned Work===
+
===Assigned===
  
:*Sonnenbergs, C 1, "What is the Microbiota and Why Should I Care?" (26)
+
:*Hare and Woods – “Humans Evolved to be Friendly” – (1-19; 18) -- Key concepts: self-domestication, cooperative communication
:*Read [[Nutrition, Satisfaction, Practicality and Dietary Change]].  At least up to, "Designing your diet with NSP.
 
:*View this movie on the Microbiome:
 
::*'''Microbiota: The Amazing Gut'''. 2019. Sylvie Gilman. "Hidden deep in our intestines, 100,000 billion bacteria are keeping us healthy by producing a range of molecules. Although their names may be perplexing: Fecali bacterium, Roseburia, Akkermansia mucinifila, Eubacterium halli, as well as being invisible to the naked eye, they could revolutionize the future of medicine. That is, if our modern lifestyle doesn't wipe them out first."  On Amazon Prime.  [https://www.amazon.com/gp/video/detail/B08G7PX2XD/ref=atv_dp_amz_det_c_UTPsmN_1_1/ref=dv_web_auth_no_re_sig?ie=UTF8&]
 
::*If you've never seen "Food INC", please plan to watch it some time.  A copy is in the shared folder.
 
  
 
===In-Class===
 
===In-Class===
  
:*Review of 1st Day Food Survey
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:*Everyday Ethics: What kind of conversation is an ethical conversation
:*NSP segment
+
:*Writing:  Looking at Gossip writing.
  
===Using the NSP model to think about dietary design and dietary goals===
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===Writing Workshop===
  
:*Working from the wiki document [[Nutrition,_Satisfaction,_Practicality_and_Dietary_Change]] we will look at some of the interactions of N, S, and P.
+
====Some writing concepts - Review of first writing====
  
===Visual Aids for thinking about your Microbiota===
+
:*A general challenge of good writing -- '''Getting outside of your head''' -- looking at the writing as if you didn't write it.
  
[[file:intestines.jpg]]
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:*Here are a few good writing concepts to look for in the samples on the handout.
 +
::*'''Good starts''' -- Without good introductions and signals of organization and thesis readers are disoriented and confused.  Set context by framing the topic.  Tell your readers where you are going to take them.  Sometime you will find a “hook” to start with.  Something relevant to the topic that has high interest. 
 +
::*'''Flow''' -- How well does one sentence follow another?  Do you notice places where flow is interrupted? When you see good flow, try to notice how it is achieved, at the level of wording and sentence structure.
 +
::*'''Efficient writing''' -- Literally, how much you say with so many words.  Awkward phrasing and limited word choice reduce efficiency.
  
[[File:microbiomepic.png]]
+
:*Review of writing samples.
  
===Sylvie Gilman, "Microbiota: The Amazing Powers of the Gut"===
+
::*Get into your groups and read one of the two practice writing papers on the handout (not your section).  Give yourselves about two minutes to read it.  Then, in a brief discussion, keep track of what was good about the writing and what might still be improved. Do the same with the second one. Does it do some things better or worse than the first? Then, if you have time, randomly pick one that wasn't on the "nominated list", read it and compare it to the first two.
  
:*Opening scene: Birth of a child.  We are colonized at birth.
 
  
:*Microbiota research -- stools.  Sequencing technology.  The microbiome is the collective 100,000 billion.  More than # of cells in your body.  Why?  (extended genome hypothesis -- example Vitamin C)
+
===Hare and Woods – “Humans Evolved to be Friendly”===
  
:*Meet the Sonnenbergs!  5:10 - Microbes manufacture compounds, drugs for usDigestion, disease protection, vitamin production, brain effects (serotonin).  Analogy to a forest.
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:*Homo is the genus — there were others, not just Neanderthals(Ok, let’s watch a Geico Caveman commercial [https://youtu.be/-Y7HDXBVbfc?si=LrENBU1_yP5foUGi]).
  
:*'''Effects of modern diet''' - less genetic variety.  More thinning.  Switches to African aboriginal eatersJeff Leach, “Dr. Shit”.  Hudza in Tanzania.  2x diversity of gut microbesAmazon study, also.  50% more diverse.  Ancestral lifestyles maintain microbiome diversity.  
+
:*Not obvious that we were going to succeedNeanderthals were smart, had culture, fine motor skills (maybe speech)Bigger, stronger.
  
:*14:15 — '''effects of antibiotics'''.  Can cause extinction of species.  Like a bomb.  Mouse studies - even short courses of antibiotics can affect metabolism — weight gain.  Immune system changed.  Asthma.  Effects on young mice more profound.  Possible hypothesis: early exposure < 6 months predicts obesity and asthma by age 7.  
+
:*Major claim: Sapiens advantages may have include self-domestication and the changes that comes with that.  
  
:*18:14 — Caesarean births. More research by Maria Gloria Dominguez-Bello, Rutgers. New practice of feeding c-section babies with mix of vaginal germs.   
+
:*cooperative communication, shared intentionality, theory of mind.   
  
:*Back to Hudza — health of gut depends on health of environment around us. '''high fiber diet''' may be a variable.  22:30. What is effect of low fiber diet on individual and generations?  Short chain fatty acids SCFAs (also discussed in Sonnenberg readingErica Sonnenberg — mouse study of low fiber diet over 4 generations.  Loss of 1/2 of diversity.   
+
:*morphology of skeletons and skulls is influenced by neurohormonesEvidence trail.   
  
:*25:05 — '''Effects of food additives''': Emulsifiers in industrial ice cream and other industrial foods. E433 and E466 - Two widespread emulsifiers in industrial foods (ice cream, salad dressings, candy)Mouse studies again - loss of diversity and thinning of gut mucus. 28:05.  Produces intestinal inflammation, obesity, and type 2 diabetes. 27:55 - cool mouse gut cross section showing mucus layer! >anxiety! (Note how this affects your perception of the supermarket).  
+
:*bonobos are “wild domesticates”. - dogs are the best exampleAlso engage in cooperative communicationAnd they typically love us!   
  
:*'''Obesity research''' suggest microbiota differences. 32:26 - Study: Same diet, different outcomes, correlated with MB diversity.   
+
:*dogs and wolves have common ancestor, the Ice Age wolf. Domestication involve genomic change, not just about “taming a wild animal”.  Physical traits of domestication syndrome (3).   
  
:*'''Inflammatory bowel disease''' also Crone’s diseaseAbsence of ''Faecalibacterium prausnitzii'' (FP) implicatedMore mouse studies. FP has protective effect. Edge of research: Can we add missing bacteria to remedy these conditions?
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:*Belyaev wolf breeding experiments in Siberia 1959 — 50 generations foxes to domesticateGeneral story: relatively friendly member of wild species hang out near human garbage dump, reproductive advantage, interbred.  Then maybe we warmed up to them too.  So maybe wolves were somewhat self-domesticated at first(In Food studies, also pigs.).  
  
:*'''Fecal transplants''' 37:30. ''Clostridium difficile'' infection causes 30,000 deaths a yearOften following heavy antibiotic treatmentHigh cure rate >90%.
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:*14K to 40K y.agoHumans almost eradicate wild wolves300K wolves, 1 billion dogs.
  
:*41:30 Fecal Bank. Open biome, USA. Very selective 3%!. 10,000 treatments a year. 44:15: Segment on Crone’s patient. Tom Gravel.  Approached his neighbor for donor stool.  200 donations!  CuredHis gastroent impressedDon't try this at home!
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:*And us? Changes around 80K y.ago. Middle Pleistocene(5) read Human domesticate are “feminized” versions of earlier Homo Sapien.   
  
:*Oncology segment — immunotherapyImpoverished microbiota may diminish efficacy of anti-cancer treatmentsIn human study, effects from anti-biopics prior to cancer treatment, less effective response to treatmentA specific bacterium identified: ''Akkermansia Muciniphila''More mice.
+
:*Experimental corroboration - SSRI treated baby mice get globular head shapeNeanderthals football shaped headsLower testosterone, higher serotonin, more oxytocinResearch links oxytocin to cooperative behaviors.   
  
:*Terlingua - Also a site for LeachThink like an ecologist about your gut'''6 week high fiber diet can increase diversity by 30%.''' 56:00 Listen to the Sonnenbergs. Treat your gut like a pet!
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:*Chimps, bonobos, humans on strangers:  we have a category “intragroup stranger” (a stranger who we regard as a group member)Chimps generally hostile to strangers, bonobos friendlier to bonobo strangersWhat did this do for us?  (6).   
  
===Sonnenbergs, C 1, "What is the Microbiota and Why Should I Care?"===
+
:*Also about 80K y.ago we got more consistent in implementing the kind of culture that comes from cooperation.  Expanded social networks mean more information flows.  50K y.ago jewelry, cool 3d animal paintings. 
  
:*How the world looks to a microbiologist! "Without microbes humans wouldn't exist, but if we all disappeared, few of them would notice." 10
+
:*7: But we are also an incredibly cruel species.   
:*Introduction to the Tube and digestion
 
:*Microbiota Case against the Western Diet
 
::*Inflammatory Bowel Disease.  People on Western Diet wo/IBD may still not have healthy M
 
::*Sets the history of human diet in context. Agriculture already a big change, but then industrial ag / industrial foods
 
::*Adaptability of M remarkable.  Makes us omnivores.  “Microbiota plasticity”
 
::*Baseline M - cant' be health Western Diet eaters.  studies of groups like Hadza -- far more diverse.
 
::*19 - Evolved Symbiotic relationship between us and bacteria --
 
:::*Microbiota — Microbiome (the collective genotypes of the residents intestines).  Example of Japanese seaweed consuming bacteria. 
 
:::*types of symbiotic relationship - parasitic, commensal (one party benefits, little or no effect on the other), mutualism.  Microbiota and us have a symbiotic, mutualist relationship.  Think of them as an extension of our genome!
 
:::*The heart warming story of Tremblaya princeps and Moranella endobia.  (21)  -- why we should be happy mutualists.  Delegation and division of labor might create resiliance.  But our fates are linked!
 
  
:*22-30 - Cultural History and History of Science on Bacteria -- or, how germs got such a bad name.
+
:*Oxytocin has another side“Mama bear hormone”. Hamster momsSocial bonding and aggression to out groups go together.   
::*Pasteur -- germ theory of diseases.   
 
::*The Great Stink 1858 London, Miasma theory disproved, Cholera bacterium, not isolated until near end of century. Dr. Robert KochBecause of this history we tend to think of bacteria as threats. 
 
::*60-70's: Abbigail Salyers: early pioneer, 2008: Human Microbiome Project. Note how recent this field is.  One of the pioneers was still working in 2005.   
 
::*Note research questions on p. 28.
 
::*Contemporary research: gnotobiotic mice.  early fecal transplant studies of.[[https://gordonlab.wustl.edu/index_2017.html Dr. Jeffrey Gordon]].
 
  
 +
:*What Wrangham calls “the Goodness Paradox” “Humans become more violent when those we evolved to live more intensely were threatened.”
  
:*Some functions of the Microbiota:
+
:*Positive implications.  We can expand the circle.  Whites/Black schooled together have more cooperative behaviors in later life (ok with interracial marriage, have friends from other group…)
::*Harvesting calories from MACs
 
::*immune system support
 
::*resistance to harmful bacteria
 
::*regulation of metabolism
 
::*production of seratonin
 
::*production of SCFAs, which affect weight control
 
::*involved in production of anti-carcinogenic compounds.
 
::*prevention of IBS and other disorders of the gut.
 
  
===Some implications of Microbiome research===
+
:*Very interesting comment — Changing behavior changes attitudes.
  
:*Food feeds you and your extended genomeYou are eating for trillions!
+
===Everyday Ethics: What kind of conversation is an ethical conversation===
:*Macronutrient information is only part of assessing the potential nutrition from food. MACs (next class)
+
 
:*It’s all about the tube!
+
:*Ethical conversations and analyses are about evaluating "values and expectations" - claims that we ought to adopt or reject some value(s) and the associated behavior motivated by those values.  
 +
 
 +
:*So what are some of the unwritten, but widely acknowledged rules for having an ethical conversation? What are the legitimate "moves" you can make in an ethical conversation?  What moves would earn you a yellow or red card. 
 +
 
 +
:*'''Illegitimate moves''':
 +
::*Appealing to only one person's or group's interests.
 +
:::*"What's right is what serves my interests!" vs. "In this circumstance, it is morally permissible for everyone to pursue their interests"
 +
::*Denying the standing (need for consideration) of a person or group arbitrarily. "
 +
:::*"Everyone deserves human rights except group X"
 +
::*Most illicit appeals in informal logic (fallacies): ''ad hominems'' and appeals to pity, ignorance, etc.
 +
 
 +
:*'''Legitimate moves:'''
 +
::*Appealing to broadly held values about human life and human dignity.
 +
::*Appealing to cultural and local norms that may be considered well justified.
 +
::*Appealing to objective knowledge claims that may support or invalidate premises. 
 +
::*Calling into question these norms or their application, often by:
 +
:::*1. Conceptual analysis -- What does it mean to value human life? How will we know that we are guaranteeing human dignity?
 +
:::*2. Advocacy for specific understanding of human nature or human needs. 
 +
:::*3. Showing that some value proposition will or will not function to promote desirable outcomes.

Latest revision as of 19:21, 23 January 2025

4: JAN 23.

Assigned

  • Hare and Woods – “Humans Evolved to be Friendly” – (1-19; 18) -- Key concepts: self-domestication, cooperative communication

In-Class

  • Everyday Ethics: What kind of conversation is an ethical conversation
  • Writing: Looking at Gossip writing.

Writing Workshop

Some writing concepts - Review of first writing

  • A general challenge of good writing -- Getting outside of your head -- looking at the writing as if you didn't write it.
  • Here are a few good writing concepts to look for in the samples on the handout.
  • Good starts -- Without good introductions and signals of organization and thesis readers are disoriented and confused. Set context by framing the topic. Tell your readers where you are going to take them. Sometime you will find a “hook” to start with. Something relevant to the topic that has high interest.
  • Flow -- How well does one sentence follow another? Do you notice places where flow is interrupted? When you see good flow, try to notice how it is achieved, at the level of wording and sentence structure.
  • Efficient writing -- Literally, how much you say with so many words. Awkward phrasing and limited word choice reduce efficiency.
  • Review of writing samples.
  • Get into your groups and read one of the two practice writing papers on the handout (not your section). Give yourselves about two minutes to read it. Then, in a brief discussion, keep track of what was good about the writing and what might still be improved. Do the same with the second one. Does it do some things better or worse than the first? Then, if you have time, randomly pick one that wasn't on the "nominated list", read it and compare it to the first two.


Hare and Woods – “Humans Evolved to be Friendly”

  • Homo is the genus — there were others, not just Neanderthals. (Ok, let’s watch a Geico Caveman commercial [1]).
  • Not obvious that we were going to succeed. Neanderthals were smart, had culture, fine motor skills (maybe speech). Bigger, stronger.
  • Major claim: Sapiens advantages may have include self-domestication and the changes that comes with that.
  • cooperative communication, shared intentionality, theory of mind.
  • morphology of skeletons and skulls is influenced by neurohormones. Evidence trail.
  • bonobos are “wild domesticates”. - dogs are the best example. Also engage in cooperative communication. And they typically love us!
  • dogs and wolves have common ancestor, the Ice Age wolf. Domestication involve genomic change, not just about “taming a wild animal”. Physical traits of domestication syndrome (3).
  • Belyaev wolf breeding experiments in Siberia — 1959 — 50 generations foxes to domesticate. General story: relatively friendly member of wild species hang out near human garbage dump, reproductive advantage, interbred. Then maybe we warmed up to them too. So maybe wolves were somewhat self-domesticated at first. (In Food studies, also pigs.).
  • 14K to 40K y.ago. Humans almost eradicate wild wolves. 300K wolves, 1 billion dogs.
  • And us? Changes around 80K y.ago. Middle Pleistocene. (5) read Human domesticate are “feminized” versions of earlier Homo Sapien.
  • Experimental corroboration - SSRI treated baby mice get globular head shape. Neanderthals football shaped heads. Lower testosterone, higher serotonin, more oxytocin. Research links oxytocin to cooperative behaviors.
  • Chimps, bonobos, humans on strangers: we have a category “intragroup stranger” (a stranger who we regard as a group member). Chimps generally hostile to strangers, bonobos friendlier to bonobo strangers. What did this do for us? (6).
  • Also about 80K y.ago we got more consistent in implementing the kind of culture that comes from cooperation. Expanded social networks mean more information flows. 50K y.ago jewelry, cool 3d animal paintings.
  • 7: But we are also an incredibly cruel species.
  • Oxytocin has another side. “Mama bear hormone”. Hamster moms. Social bonding and aggression to out groups go together.
  • What Wrangham calls “the Goodness Paradox” “Humans become more violent when those we evolved to live more intensely were threatened.”
  • Positive implications. We can expand the circle. Whites/Black schooled together have more cooperative behaviors in later life (ok with interracial marriage, have friends from other group…)
  • Very interesting comment — Changing behavior changes attitudes.

Everyday Ethics: What kind of conversation is an ethical conversation

  • Ethical conversations and analyses are about evaluating "values and expectations" - claims that we ought to adopt or reject some value(s) and the associated behavior motivated by those values.
  • So what are some of the unwritten, but widely acknowledged rules for having an ethical conversation? What are the legitimate "moves" you can make in an ethical conversation? What moves would earn you a yellow or red card.
  • Illegitimate moves:
  • Appealing to only one person's or group's interests.
  • "What's right is what serves my interests!" vs. "In this circumstance, it is morally permissible for everyone to pursue their interests"
  • Denying the standing (need for consideration) of a person or group arbitrarily. "
  • "Everyone deserves human rights except group X"
  • Most illicit appeals in informal logic (fallacies): ad hominems and appeals to pity, ignorance, etc.
  • Legitimate moves:
  • Appealing to broadly held values about human life and human dignity.
  • Appealing to cultural and local norms that may be considered well justified.
  • Appealing to objective knowledge claims that may support or invalidate premises.
  • Calling into question these norms or their application, often by:
  • 1. Conceptual analysis -- What does it mean to value human life? How will we know that we are guaranteeing human dignity?
  • 2. Advocacy for specific understanding of human nature or human needs.
  • 3. Showing that some value proposition will or will not function to promote desirable outcomes.