Difference between revisions of "JAN 31"

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==4: JAN 31==
+
==5. JAN 31==
  
===Assigned===
+
===Assigned Work===
  
:*Sapolsky, Chapter 10: The Evolution of Human Behavior 328-374 (46). For this class read only pages 328-354 (26). Use notes below also for part two of this chapter.
+
:*Nix, Stacy. Chapter 2: "Carbohydrates" ''Williams' Basic Nutrition and Diet Therapy''  (pp. 13-30).
 +
:*Complete [https://docs.google.com/forms/d/e/1FAIpQLSdpGUY8XJVDBpzIuWVIWJNaZ3s0VNMkKuL1580mir2wSfRjqQ/viewform?usp=sf_link Carbohydrate Worksheet] by Wednesday night, midnight.
 +
:*van Tulleken, Chris. C14 "Additive Anxiety" (208-221; 13)
 +
:*SW1: What's important about your microbiota? '''See below for due date.'''
  
:*Utilitarianism:
+
===In-class===
::*Watch:
 
:::*The Trolley Problem [http://www.youtube.com/watch?v=6WB3Q5EF4Sg The Trolley Problem].
 
:::*PBS Philosophy Crash course on utilitarianism.  [https://www.youtube.com/watch?v=-a739VjqdSI]
 
::*Recommended to browse:
 
:::*Self-driving cars with Trolley problems: [http://www.cnet.com/news/self-driving-car-advocates-tangle-with-messy-morality/]
 
:::*[https://www.theatlantic.com/health/archive/2014/10/the-cold-logic-of-drunk-people/381908/ The Cold Logic of Drunk People]
 
:::*Variations on the Trolley Problem: [[http://www.mcsweeneys.net/articles/lesser-known-trolley-problem-variations ]]
 
  
===In-class content===
+
:*Discussion of SW1 assignment and prompt.  Some reminders about good writing.
 +
:*Review of [[Assignment Rubric]]
  
:*Philosophical Method: Ethics as a kind of language game, or conversational constraints on moral discourse.  Today, before turning to Sapolsky, we'll do a short workshop on how ethical conversations work. 
+
===Some writing concepts===
 
 
:*Reviewing samples of first writing
 
 
 
===Some writing concepts - Review of first writing===
 
  
 
:*A general challenge of good writing -- '''Getting outside of your head''' -- looking at the writing as if you didn't write it.
 
:*A general challenge of good writing -- '''Getting outside of your head''' -- looking at the writing as if you didn't write it.
Line 26: Line 19:
 
:*Here are a few good writing concepts to look for in the samples on the handout.
 
:*Here are a few good writing concepts to look for in the samples on the handout.
 
::*'''Flow''' -- How well does one sentence follow another?  Do you notice places where flow is interrupted?
 
::*'''Flow''' -- How well does one sentence follow another?  Do you notice places where flow is interrupted?
::*'''Good starts''' -- Without good introductions and signals of organization and thesis readers are disoriented and confused.  Set context by framing the topic.  Tell your readers where you are going to take them.
+
::*'''Good starts''' -- Without good introductions and signals of organization and thesis readers are disoriented and confused.  Set context by framing the topic.  Tell your readers where you are going to take them. Go ahead and tell them your main point.
 
::*'''Efficient writing''' -- Literally, how much you say with so many words.  Awkward phrasing and limited word choice reduce efficiency.
 
::*'''Efficient writing''' -- Literally, how much you say with so many words.  Awkward phrasing and limited word choice reduce efficiency.
  
:*Review of writing samples. 
+
===van Tulleken, Chris. C14 "Additive Anxiety"===
::*I haven't looked at all of the writing yet, but I will share some samples, mostly of good things you are doing.  The samples will be drawn from the other section of Ethics.  They all do many good things as writers, but there are some differences.
 
 
 
===Ethics as a "language game"===
 
 
 
:*Well, not really a game.  The term comes from a famous philosopher, Ludwig Wittgenstein, who was interested in how language is similar to a games. For example, there are lots of rules to using language, not just grammar, etc., but social rules.  Like the rules for conversations.  You can know a language and still not be very sophisticated in having a conversation!
 
 
 
:*Ethical conversations and analyses are general about evaluating "value propositions" - claims that we ought to adopt or reject some value(s) and the associate behavior motivated by those values.
 
 
 
:*So what are some of the unwritten, but widely acknowledged rules for having an ethical conversation?  What are the legitimate "moves" you can make in an ethical conversation?  What moves would earn you a yellow or red card. 
 
 
 
:*'''Illegitimate moves''':
 
::*appealing to only one person's or group's interests.
 
:::*"What's right is what serves my interests!" vs. "In many circumstances, it is morally permissible for everyone to pursue their interests"
 
::*denying the standing (need for consideration) of a person or group arbitrarily. "
 
:::*"Everyone deserves human rights except group X"
 
::*most illicit appeals in informal logic (fallacies): ''ad hominems'' and appeals to pity, ignorance, etc.
 
 
 
:*'''Legitimate moves:'''
 
::*appealing to broadly held values about human life and human dignity.
 
::*appealing to cultural and local norms that may be considered well justified.
 
::*appealing to objective knowledge claims that may support or invalidate premises. 
 
::*calling into question these norms or their application, often by:
 
:::*1. conceptual analysis -- What does it mean to value human life?
 
:::*2. advocacy for specific understanding of human nature or human needs. 
 
:::*3. showing that some value proposition will or will not function to promote desirable outcomes.
 
 
 
:*'''Constraints''' (or rules of thumb) we might recommend to improve moral or political discourse:
 
:::*observe norms of civil discourse,
 
:::*avoid calling people liars, implying that they are stupid for not agreeing with you, or impugning bad motives,
 
:::*present others' views in ways that shows empathetic understanding,
 
:::*recognize common ground,
 
:::*show respect for perspectives that seem tied to a person's normal identity, including their personal experience, ethnicity, gender identity/expression, or socio-economic status (SES).  Basic and relatively fixed "values orientation" may be part of identity.
 
 
 
===Sapolsky, Chapter 10: The Evolution of Human Behavior Part 1 328-354===
 
 
 
:*Evolution 101 — 3 steps - Inheritance - Variation - Fitness
 
 
 
:*Some misconceptions:
 
::*1. Evolution is not so much about survival as reproduction.  Antagonistic pleiotropy — sperm early, cancer later.
 
::*2. The living are not better adapted than the extinct.  Fitness isn't "prospective"
 
::*3. Evolution is "just a “theory”
 
 
 
::*Sexual selection and natural selection.  Example of peacocks — trade offs between two forms of selection. 
 
 
 
::*Sociobiology and evolutionary psychology.  Premise: Evolution selects for social and psychological traits and behaviors that improve fitness -- just like it selects for bodies that stand up to selection pressures. 
 
  
::*Marlin Perkins and Mutal of Omaha’s Wild KingdomBad ideas about evolution of altruistic species behaviorGroup selection doesn’t work that way.
+
:*Mention premise of the bookHe goes on an ultra-processed diet (as in ''Fast Food Nation'')Mostly science reporting on ultra-processed foods.  
  
:*'''Individual Selection''' — 334: competitive infanticide: why langur monkeys kill babiesHow females develop a false estrus to fight back.  (Working against mountain gorillas these days.)
+
:*Pret a Manger - PR of brand v reality of additives.   
  
:*'''Kin Selection''' — 336:  Basic idea: your nearest kin has most of your genes.  Haldane, “I’d gladly lay down my life for two brothers or eight cousins.”  Allomothering.  Grooming behaviors reflect closeness.  337: vervet monkey study - A treats B badly, then B treat A and A's kin badly. Playback studies.  These studies show in various ways how warning behaviors track kinship relationships in social primates.
+
:*2007 UK study in the ''Lancet'' - additive enhanced drinks and hyperactivity in kids.  
  
::*problem for kin selection — avoiding inbreeding. Many species mate with 1-3rd cousinsSperm aggregation.  Malagasy giant jumping rat. 340 - women prefer smell of near relatives over unrelated.
+
:*EU: 2,000 approved additives. US Unknown, but 10,000 officially approvedRead at 210 - list.
  
:*How do animal recognize kin? Major histocompatibility complex (MHC) gives many animals olfactory recognition of kin. Other mechanisms: songs, vaginal fluid smell, milk.   
+
:*Focuses on emulsifiers - (digress a moment on gastronomy value of natural emulsification)
 +
::*An ingredient list can say “lecithin” which is natural emulsifier, but could by a processed version.  
 +
::*E472e or DATEM (Panodan is DuPont’s brand) - processed from fats (lecithin).  Partly why shelf bread stays springy.
 +
::*PFOA - another DuPont additive read at 212 - also poisoned drinking water in W VA. Note legal strategy popular now - unload division with liabilities.   
  
:*How do we do kin selection?  Pseudo-kin selection or “green beard” effects.  We are not limited to actual kin, any conspicuous feature (like a green beard)Humans show green beard effectsRelated to parochialism and xenophobia. It could also be that our preference for humans over non-humans is a big green bread effect.   
+
:*Microbiota section 213ff
 +
::*viruses, pages, bacteria, protozoans, archaea, fungi, a few worms and mites!
 +
::*Nice point about fibreIt’s important because we can’t digest it. But they can.
 +
::*SCFAs mentioned here.   
 +
::*Dysbiosis - disruptions in the MB that lead to harmful organisms taking up residence.   
  
:*'''Reciprocal Altruism.'''
+
:*Evidence on two emulsifiers: carboxymethylcellulose and polysorbate 80.  Found in pickles, ice cream, aerosolized whipping cream, toothpaste, and hair and skin products.  2015 study in ''Nature'' found gut damage in mice.  Leaky gut.  Helicobacter pylori - a nasty one implicated in cancer and ulcers.
  
::*Don't just think about evolution as promoting competition toward extinction. Equilibriums are important. Sustaining conditions that meet selection pressures. (problems that can be addressed by values) Maintaining a good community.
+
:*Maltodexdrins - synthetic sugar molecules in UPF. - read harms at bot 219.
  
::*Reciprocal altruism is a third way that evolution shapes human behaviorUnrelated individuals cooperate across nature (fish in schools, birds in formation, herds).  "Geometry of the selfish herd."  Also unrelated primates.  Important 1971 paper by Trivers (344) on reciprocal altruism. How social species incur a fitness cost to benefit another individual with expectation of reciprocation. 
+
:*Xanthan gums - note usesStill understanding its effects, but it has changed our guts.
  
:*Requirements for reciprocal altruism.  Social species, frequent interactions, recognition of individuals (so, also memory).
+
===SW1: What's important about your microbiota?===
  
::*cheating and freeriding can create a "Red Queen" situation.   
+
:*'''Stage 1''': Please write an 600 hundred word maximum answer to the following question by '''Monday, February 5th, 2024, 11:59pm.'''
 +
::*Topic: We've been following science research on the microbiota and connecting that research to practical questions about our diets.  What are some of the general lessons for us coming out of this research and what might it tell us about ''the nature of food and healthy eating''?  In your answer try to give both the "big picture" and highlight some of the more remarkable and interesting results of microbiome research.   
  
:*Two big questions: when is cooperation optimal, how can altruism start?
+
:*'''Advice about collaboration''': Collaboration is part of the academic process and the intellectual world that college courses are based on, so it is important to me that you have the possibility to collaborate.  I encourage you to collaborate with other students, but only up to the point of sharing ideas, references to class notes, and your own notes, '''verbally'''.  Collaboration  is also a great way to make sure that a high average level of learning and development occurs in the class.  The best way to avoid plagiarism is to NOT share text of draft answers or outlines of your answer.  Keep it verbal.  Generate your own examples. 
  
:*What strategy for cooperating is optimal?
+
:*'''Preparing your document for submission to the dropbox''':
  
::*background to Game Theory - John von Neumann. Prisoner's Dilemma connected biologists to game theorists.  Short video on PD: [https://www.youtube.com/watch?v=TJCGTNIwmv8]
+
::# To assure anonymity, you must remove your name from the the "author name" that you may have provided when you set up your word processing application. For instructions on removing your name from an Word or Google document, [[https://wiki.gonzaga.edu/alfino/index.php/Removing_your_name_from_a_Word_file click here]].
::*Basics of a Prisoner's Dilemma payoff: A&B cooperate (hold out): 1 year: A cooperates, B defects (rats out B by confessing): B walks and A gets three years. Cooperation is best, but only if you can count on it. If not, then you have to think of average payoffs or outcomes. Some some sets of payoffs, thinking this way leads to defection, the most rational choice, but not optimalQuite a little dilemma.
+
::# Please format your answer in double spaced text, in a typical 12 point font, and using normal margins. Do not add spaces between paragraphs and indent the first line of each paragraph.  
 +
::# Do not put your name in the file or filename.  You may put your student ID number in the file, but not in the filename. Save your file in .docx format with the name: '''Microbiota'''.
 +
::# Please add a "word count" at the end of your writing.
 +
::# To turn in your assignment, log into courses.alfino.org, click on the “#1 - Points - SW1” dropbox.
 +
::# Please try to meet the deadline for this assignmentWe will be moving on to peer review and it is important to have all of the papers in for that work.  
  
::*defection is optimal for single round PD, but what about 3 rounds. Still best to defect. What about "iterated" (uncertain number of rounds)?
+
:*'''Stage 2''': Please evaluate '''four''' student answers and provide brief comments and a score. Review the [[Assignment Rubric]] for this exercise.  We will be using the Flow and Content areas of the rubric for this assignment. Complete your evaluations and scoring by '''Friday, February 9, 2024 11:59pm.'''
 +
 
 +
::*To determine the papers you need to peer review, use the key list I sent you by email. You will see a worksheet with saint names in alphabetically order, along with animal names. Find your saint name and review the next four (4) animals' work below your animal name. If you get to the bottom of the list before reaching 4 animals, go to the top of the list and continue. 
  
::*Axelrod's challenge: Optimal strategy for iterated PD. Winner: Anatol Rapoport:  Cooperation on 1st round and then match opponent's previous behavior.  "Tit for Tat"  Always works toward a draw, or slight negative outcome. Not that Tit for Tat tilts toward cooperation, but avoids being a sucker and punishes defectors.  famous paper in 1981 by Axelrod and Hamilton.  
+
::*Use [https://docs.google.com/forms/d/e/1FAIpQLScOI7j5oxnVd7Sv192fVFYVSiuK5bfwpBLkossVXjC2jir75Q/viewform?usp=sf_link this Google Form] to evaluate '''four''' peer papers. Submit the form once for each review.
  
::*"Signal errors" can reduce Tit for Tat payoffsRemedies: "Contrite tit for tat (retaliate after two defections) and Forgiving (forgive 1/3 of defections)Both address the signal error problem, but have other vulnerabilities.
+
::*Some papers may arrive lateIf you are in line to review a missing paper, allow a day or two for it to show upIf it does not show up, go back to the key and review the next animal's paper, continuing until you get four reviews. Do not review more than four papers.
  
::*Mixed (genetic) strategies: You could start out with one strategy and then change to anotherHow do you go from punitive Tit for Tat to one incorporating forgiveness?  Trust.  350-351: describes a changing environment a events signal to individuals to change strategies.  Kind of a model of real life.   
+
:*'''Stage 3''': I will grade and briefly comment on your writing using the peer scores as an initial rankingAssuming the process works normally, most of my scores probably be within 1-2 points of the peer scores, plus or minus.   
  
:::*Black Hamlet fish
+
:*'''Stage 4''': Back-evaluation: After you receive your peer comments and my evaluation, take a few minutes to fill out this quick "back evaluation" rating form: [https://docs.google.com/forms/d/e/1FAIpQLSfukAB_Jmv3GO72xjZiCuPz3ZrVMP1SL-B_WGi171QxFBvPyg/viewform?usp=sf_link].  '''Fill out the form for each reviewer, but not Alfino.'''  '''You must do the back evaluation to receive credit for the whole assignment.'''  Failing to give back-evaluations unfairly affects other classmates.
  
:::*Stickleback fish
+
::*Back evaluations are due '''TBD at midnight'''.
  
::*But skeptical that tit for tat has been found outside humans.
+
===Nix, Chapter 2, "Carbohydrates"===
  
===Philosophical Moral Theories: Consequentialism -- Utilitarianism===
+
:*'''Nature of Carbs'''
 +
::*Carbs are a source of short term energy.  All Carbs break down into sugars during metabolism.
 +
::*Scale of simple to complex.  Simple sugars (monosacharides) don't even require digestion.  Starchs are complex and "slow burning".
 +
::*Limits to the "energy" metaphor:
 +
:::*carb levels and types help regulate other processes like insulin response,
 +
:::*fiber helps with useful bacteria production, appears to reduce colon cancer, helps with bowel function and avoidance of diverticulosis.
 +
:::*carb types and level signal body to break down protein for energy or not. 
 +
:::*soluble fiber binds bile acids, lowering cholesterol
  
:*Let's meet Jeremy Bentham[https://en.wikipedia.org/wiki/Jeremy_Bentham]
+
::*Classes of Carbs:
 +
:::*Mono and di-saccharides are “simple carbs”.  Glucose is the form that sugar takes in your blood. 
 +
:::*Polysaccarides are found in starches: grains, rice, corn.  Also in plant proteins: legumes.   
 +
:::*Per capita HFCS (high fructose corn syrup) up from .12 tsp daily in 1970 to 11.18 tsp in 2008. p. 15
 +
::*Fibers
 +
:::*Soluble and insoluble - soluble fiber binds bile acids and lowers blood cholesterol.
 +
:::*Insoluable are roughly what the Sonnenbergs were calling “MACs”.
  
:*Brief historical intro to utilitarians: Early industrial society, "social statics" (early efforts to measure social conditions)Utilitarians were seen as reformers.
+
:::*Note warning on high fiber low iron-rich dietPhytic acid in this diet can cause iron deficiency. You can get too much fiber, but most Americans don't.
  
::*Eudaimonistic(about Happiness or Well-Being) vs. Non-Eudaimonistic (Duty)
+
:*'''Functions of Carbs'''
:::*Two views:  
+
::*reserve fuel supply is stored as glycogen in muscles [[http://www.nature.com/scitable/topicpage/cell-energy-and-cell-functions-14024533]] and blood sugar.  Roughly 1-2 hours of aerobic exercise.  glycogen also stored in the liver to regulate blood sugar.
::::*1) Morality is fundamentally eudaimonistic "in the long run," even if it in particular proximate circumstances in does not always involve positive emotions (includes Utilitarians).  
+
::*Carbs keep us from going into ketosis, but as we've noted, you can have a diet based on having your body in a state of ketosis (Paleo).
::::*2) Morality and moral responses realize disinterested values like reason and justice, that are not related to promoting happy outcomes (Kant / Duty ethics).
 
  
:*'''Fundamental consequentialist intuition''': Most of what's important about morality can be seen in outcomes of our actions that promote happiness and human well-being.  (Recall "Intentions-Acts-Consequences")
+
:*'''Digestion'''
 +
::*Primarily in small intestine, through enzymes such as amalyse from the pancreas, and from the "microvilli" of the intestine which contain specific di-saccaridases: sucrase, lactase, and maltase.  (digression from p. 26 text box on dairying as textbook case of gene-culture co-evolution.)
 +
::*Saliva contains enzymes that break down carbs.
 +
::*Glycemic index vs. Glycemic load [https://lpi.oregonstate.edu/mic/food-beverages/glycemic-index-glycemic-load#glycemic-load link for GI vs. GL]
 +
::*Note how our bodies are designed to chemically and mechanically break down carbs.  There is no need to outsource this to an industrial food!
  
:*Basic principles of utilitarian thought:
+
::*As we learned from study of the microbiome, you can think of carbs as feeding both you and them (the other 15 trillion organisms you walk around with in your gut).  Neither fat nor protein get into the large intestine in significant amounts.  We feed our gut bacteria with carbs. 
  
::*'''Equal Happiness Principle''': Everyone's happiness matters to them as much as mine does to me. Everyone's interests have equal weight.  (Note this is a rational principle.  Emotionally, it's false.)
+
:*'''Recommendations'''
:::*Note on method: this is a way to universalize.  Recall earlier discussion about conditions for ethical discourse. Ethics is about figuring out when we need to take a moral concern about something and, if we do, then we take on constraint (conversational): universalizability, equality of interests. 
 
  
::*'''Principle of Utility''': Act always so that you promote the greatest good for the greatest number.   
+
::*Decrease added sugar to less than 10% of calorie intakeCurrent ly 28 teaspoons of added sugar a day.)
:::*Hedonic version: Act to promote the greatest pleasure ...
 
:::*Classical utilitarian: greatest balance of range of qualitatively diverse pleasures and aspects of well-being.
 
:::*Preference utilitarian version: Act to maximally fulfill our interest in acting on our preferences.
 
  
::*But what is utility?  What is a preference?
+
::*Increase proportion of complex carbs(But also, following Kessler and the Sonnenbergs, distinguish complex carbs that are in forms that reach your MB.)
::*'''Utility''': pleasure, what is useful, happiness, well-being.   
 
:::*Is the utilitarian committed to maximizing happiness of individuals directly?  A utilitarian focused on promoting utility, might still acknowledge that promoting human happiness is mostly about protecting conditions for an individual's autonomous pursuit of happiness. Consider cases: When does promoting the greater good involve letting people make their own decisions vs. managing or regulating an issue centrally?
 
:::*Conditions for the pursuit of happiness:  Order, stability, opportunity, education, health, rights, liberty.
 
:::*Issue of protection of rights in utilitarian thought.   
 
::*'''Preferences''': 
 
:::*An indirect way to solve the problem of lack of agreement about goods.  Let's maximize opportunities for people to express their preferences.  Positive: pushing the question of the good life to the individual.  Negative: High levels of individualism may reduce social trust.  Lack of action on opportunities to reduce suffering. 
 
:::*Thought experiment: Returning a gun to an angry person.  Is the angry person's preference one that has to count?
 
:::*Cultural contradictions in our preferences: we prefer health, but we also "prefer" to eat the western diet.  Which preference should the utilitarian focus on?  Some preferences are based on bias or prejudice.
 
:::*Need some standard of rational or considered preference.  What a "reasonable person" would do.  Maybe less disagreement about that than "the good".  (Example: Intervening in the lives of homeless mentally ill and suffering.)
 
  
====Group Discussion: Assessing Utilitarianism====
+
::*There’s a good chance you are within the normal range for total carb intake (it's a broad range), but many of you could benefit from shifting the balance toward complex carbs.  Think about your "carb profile".  Is it tilted toward simple carbs and a high glycemic (index and load) diet? Or are you more invested in complex carbs that travel in rougher textures (with grain structure attached).
  
:*Consider applying utilitarianism to different kinds of moral problems (from interpersonal ethics to public policy questions)Identify three situations in which you would want to use utilitarianism and three situations in which you would not.
+
::* Check to be sure you are approaching <10% of carbs from refined sugar3 2 oz packages of Skittles = 750cal / 168 grams of carbs, but not a good approach!  Note this is already more than 10% of calories from refined sugar.

Latest revision as of 18:12, 31 January 2024

5. JAN 31

Assigned Work

  • Nix, Stacy. Chapter 2: "Carbohydrates" Williams' Basic Nutrition and Diet Therapy (pp. 13-30).
  • Complete Carbohydrate Worksheet by Wednesday night, midnight.
  • van Tulleken, Chris. C14 "Additive Anxiety" (208-221; 13)
  • SW1: What's important about your microbiota? See below for due date.

In-class

  • Discussion of SW1 assignment and prompt. Some reminders about good writing.
  • Review of Assignment Rubric

Some writing concepts

  • A general challenge of good writing -- Getting outside of your head -- looking at the writing as if you didn't write it.
  • Here are a few good writing concepts to look for in the samples on the handout.
  • Flow -- How well does one sentence follow another? Do you notice places where flow is interrupted?
  • Good starts -- Without good introductions and signals of organization and thesis readers are disoriented and confused. Set context by framing the topic. Tell your readers where you are going to take them. Go ahead and tell them your main point.
  • Efficient writing -- Literally, how much you say with so many words. Awkward phrasing and limited word choice reduce efficiency.

van Tulleken, Chris. C14 "Additive Anxiety"

  • Mention premise of the book. He goes on an ultra-processed diet (as in Fast Food Nation). Mostly science reporting on ultra-processed foods.
  • Pret a Manger - PR of brand v reality of additives.
  • 2007 UK study in the Lancet - additive enhanced drinks and hyperactivity in kids.
  • EU: 2,000 approved additives. US Unknown, but 10,000 officially approved. Read at 210 - list.
  • Focuses on emulsifiers - (digress a moment on gastronomy value of natural emulsification)
  • An ingredient list can say “lecithin” which is natural emulsifier, but could by a processed version.
  • E472e or DATEM (Panodan is DuPont’s brand) - processed from fats (lecithin). Partly why shelf bread stays springy.
  • PFOA - another DuPont additive read at 212 - also poisoned drinking water in W VA. Note legal strategy popular now - unload division with liabilities.
  • Microbiota section 213ff
  • viruses, pages, bacteria, protozoans, archaea, fungi, a few worms and mites!
  • Nice point about fibre. It’s important because we can’t digest it. But they can.
  • SCFAs mentioned here.
  • Dysbiosis - disruptions in the MB that lead to harmful organisms taking up residence.
  • Evidence on two emulsifiers: carboxymethylcellulose and polysorbate 80. Found in pickles, ice cream, aerosolized whipping cream, toothpaste, and hair and skin products. 2015 study in Nature found gut damage in mice. Leaky gut. Helicobacter pylori - a nasty one implicated in cancer and ulcers.
  • Maltodexdrins - synthetic sugar molecules in UPF. - read harms at bot 219.
  • Xanthan gums - note uses. Still understanding its effects, but it has changed our guts.

SW1: What's important about your microbiota?

  • Stage 1: Please write an 600 hundred word maximum answer to the following question by Monday, February 5th, 2024, 11:59pm.
  • Topic: We've been following science research on the microbiota and connecting that research to practical questions about our diets. What are some of the general lessons for us coming out of this research and what might it tell us about the nature of food and healthy eating? In your answer try to give both the "big picture" and highlight some of the more remarkable and interesting results of microbiome research.
  • Advice about collaboration: Collaboration is part of the academic process and the intellectual world that college courses are based on, so it is important to me that you have the possibility to collaborate. I encourage you to collaborate with other students, but only up to the point of sharing ideas, references to class notes, and your own notes, verbally. Collaboration is also a great way to make sure that a high average level of learning and development occurs in the class. The best way to avoid plagiarism is to NOT share text of draft answers or outlines of your answer. Keep it verbal. Generate your own examples.
  • Preparing your document for submission to the dropbox:
  1. To assure anonymity, you must remove your name from the the "author name" that you may have provided when you set up your word processing application. For instructions on removing your name from an Word or Google document, [click here].
  2. Please format your answer in double spaced text, in a typical 12 point font, and using normal margins. Do not add spaces between paragraphs and indent the first line of each paragraph.
  3. Do not put your name in the file or filename. You may put your student ID number in the file, but not in the filename. Save your file in .docx format with the name: Microbiota.
  4. Please add a "word count" at the end of your writing.
  5. To turn in your assignment, log into courses.alfino.org, click on the “#1 - Points - SW1” dropbox.
  6. Please try to meet the deadline for this assignment. We will be moving on to peer review and it is important to have all of the papers in for that work.
  • Stage 2: Please evaluate four student answers and provide brief comments and a score. Review the Assignment Rubric for this exercise. We will be using the Flow and Content areas of the rubric for this assignment. Complete your evaluations and scoring by Friday, February 9, 2024 11:59pm.
  • To determine the papers you need to peer review, use the key list I sent you by email. You will see a worksheet with saint names in alphabetically order, along with animal names. Find your saint name and review the next four (4) animals' work below your animal name. If you get to the bottom of the list before reaching 4 animals, go to the top of the list and continue.
  • Use this Google Form to evaluate four peer papers. Submit the form once for each review.
  • Some papers may arrive late. If you are in line to review a missing paper, allow a day or two for it to show up. If it does not show up, go back to the key and review the next animal's paper, continuing until you get four reviews. Do not review more than four papers.
  • Stage 3: I will grade and briefly comment on your writing using the peer scores as an initial ranking. Assuming the process works normally, most of my scores probably be within 1-2 points of the peer scores, plus or minus.
  • Stage 4: Back-evaluation: After you receive your peer comments and my evaluation, take a few minutes to fill out this quick "back evaluation" rating form: [1]. Fill out the form for each reviewer, but not Alfino. You must do the back evaluation to receive credit for the whole assignment. Failing to give back-evaluations unfairly affects other classmates.
  • Back evaluations are due TBD at midnight.

Nix, Chapter 2, "Carbohydrates"

  • Nature of Carbs
  • Carbs are a source of short term energy. All Carbs break down into sugars during metabolism.
  • Scale of simple to complex. Simple sugars (monosacharides) don't even require digestion. Starchs are complex and "slow burning".
  • Limits to the "energy" metaphor:
  • carb levels and types help regulate other processes like insulin response,
  • fiber helps with useful bacteria production, appears to reduce colon cancer, helps with bowel function and avoidance of diverticulosis.
  • carb types and level signal body to break down protein for energy or not.
  • soluble fiber binds bile acids, lowering cholesterol
  • Classes of Carbs:
  • Mono and di-saccharides are “simple carbs”. Glucose is the form that sugar takes in your blood.
  • Polysaccarides are found in starches: grains, rice, corn. Also in plant proteins: legumes.
  • Per capita HFCS (high fructose corn syrup) up from .12 tsp daily in 1970 to 11.18 tsp in 2008. p. 15
  • Fibers
  • Soluble and insoluble - soluble fiber binds bile acids and lowers blood cholesterol.
  • Insoluable are roughly what the Sonnenbergs were calling “MACs”.
  • Note warning on high fiber low iron-rich diet. Phytic acid in this diet can cause iron deficiency. You can get too much fiber, but most Americans don't.
  • Functions of Carbs
  • reserve fuel supply is stored as glycogen in muscles [[2]] and blood sugar. Roughly 1-2 hours of aerobic exercise. glycogen also stored in the liver to regulate blood sugar.
  • Carbs keep us from going into ketosis, but as we've noted, you can have a diet based on having your body in a state of ketosis (Paleo).
  • Digestion
  • Primarily in small intestine, through enzymes such as amalyse from the pancreas, and from the "microvilli" of the intestine which contain specific di-saccaridases: sucrase, lactase, and maltase. (digression from p. 26 text box on dairying as textbook case of gene-culture co-evolution.)
  • Saliva contains enzymes that break down carbs.
  • Glycemic index vs. Glycemic load link for GI vs. GL
  • Note how our bodies are designed to chemically and mechanically break down carbs. There is no need to outsource this to an industrial food!
  • As we learned from study of the microbiome, you can think of carbs as feeding both you and them (the other 15 trillion organisms you walk around with in your gut). Neither fat nor protein get into the large intestine in significant amounts. We feed our gut bacteria with carbs.
  • Recommendations
  • Decrease added sugar to less than 10% of calorie intake. Current ly 28 teaspoons of added sugar a day.)
  • Increase proportion of complex carbs. (But also, following Kessler and the Sonnenbergs, distinguish complex carbs that are in forms that reach your MB.)
  • There’s a good chance you are within the normal range for total carb intake (it's a broad range), but many of you could benefit from shifting the balance toward complex carbs. Think about your "carb profile". Is it tilted toward simple carbs and a high glycemic (index and load) diet? Or are you more invested in complex carbs that travel in rougher textures (with grain structure attached).
  • Check to be sure you are approaching <10% of carbs from refined sugar. 3 2 oz packages of Skittles = 750cal / 168 grams of carbs, but not a good approach! Note this is already more than 10% of calories from refined sugar.